thetaiotaomicron and the elevated serum glutamate concentration. Furthermore, weight-loss intervention by bariatric surgery partially reversed obesity-associated microbial and metabolic alterations in obese individuals, including the decreased abundance of B. thetaiotaomicron reduced plasma glutamate concentration and alleviated diet-induced body-weight gain and adiposity in mice. The abundance of Bacteroides thetaiotaomicron, a glutamate-fermenting commensal, was markedly decreased in obese individuals and was inversely correlated with serum glutamate concentration. We identified obesity-associated gut microbial species linked to changes in circulating metabolites. We performed a metagenome-wide association study and serum metabolomics profiling in a cohort of lean and obese, young, Chinese individuals. 15 Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark.Įmerging evidence has linked the gut microbiome to human obesity.14 National Institute of Nutrition and Seafood Research, Bergen, Norway.13 Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.12 Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.11 Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.Watson Institute of Genome Sciences, Hangzhou, China.
Assemble collections, gather morphing objects. Challenge yourself with interactive hidden object scenes and original puzzles. Complete over 40 fun and challenging mini-games. 9 Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen, China. Do not allow the Arachnoid army to conquer the Lost Lands Return to the starting point and correct the mistakes of the past - Explore over 40 stunning locations.8 CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.7 Pancreatic Disease Center, Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.6 Laboratory of Endocrinology and Metabolism, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) &Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China.5 China National GeneBank, BGI-Shenzhen, Shenzhen, China.4 Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI-Shenzhen, Shenzhen, China.